• Many different endogenous and exogenous factors must be considered in determining the cause of vesicular eruptions of the hands. Location, timing, and intensity of the eruption are influenced by several factors, such as friction, diet, and climate. Identification of the cause is essential because removal of the cause is the first step in conservative, specific treatment.
Johnson SAM. DIAGNOSIS AND TREATMENT OF VESICULAR ERUPTIONS OF THE HANDS. JAMA. 1957;163(13):1106-1111. doi:10.1001/jama.1957.02970480010003