• Over 5,000 patients having the symptom of chronic headache were evaluated for their therapeutic response to many various drugs (e.g., analgesics, sedatives, stimulants, antihistaminics, vitamins, and hormones). At present, the best method of drug evaluation is the use of the double-blind technique, in which a placebo and two or more therapeutic agents are administered to a group of untrained subjects. The selection of suitable therapy for the treatment of headache depends on the correct diagnosis, which includes the associated emotional tension and anxiety.
Friedman AP, Merritt HH. TREATMENT OF HEADACHE. JAMA. 1957;163(13):1111–1117. doi:10.1001/jama.1957.02970480015004