† One hundred children with varying degrees of asthma and ranging in age from 1 to 17 years were treated in a four-year period by intermittent positive-pressure breathing—aerosol therapy. Inspiratory positive pressures of 5 to 1 5 cm. H2O were employed; oxygen was used as the source of pressure and to nebulize the desired medicament. Aerosol medications consisted of bronchodilators, antibiotics, or surface-active or mucus-dissolving drugs as indicated. Both subjective and objective benefits occurred in 98 of the 100 children. It is believed that severe emphysema in this young age group can be corrected by intensive intermittent positive-pressure breathing— aerosol programs.
Goddard RF, Roorbach EH. INTERMITTENT POSITIVE-PRESSURE BREATHING—AEROSOL THERAPY FOR ASTHMA IN CHILDREN. JAMA. 1957;163(13):1125-1130. doi:10.1001/jama.1957.02970480029006