• Forty-two women with various manifestations of premenstrual tension were treated with meprobamate. Whether they were taking the medicament regularly after meals or in relation to symptoms, 78% of the patients studied were relieved of their original complaints. There seemed to be no difference in improvement whether the symptoms were of psychogenic or somatic origin. All patients were tested with placebos, and only 3 of the 42 felt some improvement when the placebo was substituted without their knowledge. Taking the medicament when indicated by symptoms seems to be the method of choice, and, with such a regimen, no toxic effects or withdrawal symptoms were noted.
Pennington VM. MEPROBAMATE (MILTOWN) IN PREMENSTRUAL TENSION. JAMA. 1957;164(6):638-640. doi:10.1001/jama.1957.02980060014004