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In the February 9,1957, issue of The Journal, page 454, appeared a guest editorial entitled "Predictive Value of Lipoprotein Measurements in Coronary Atherosclerosis." This editorial reported on a cooperative study in which four laboratories in different parts of the country participated. These laboratories pooled their efforts and findings after studying with standardized methods both the lipoprotein and serum cholesterol levels in a large group of subjects. The problem was to learn whether blood lipoprotein concentration offered acceptable predictability for the occurrence of coronary disease as indicated by myocardial infarction. Also of interest was the degree to which this was a better indication, if any, than the serum cholesterol concentration. The study was reported in detail in the journal Circulation. The guest editorialist for The Journal summed up the findings by writing: "... physicians need no longer develop cardiac neuroses from contemplation of some minor variation in their serum lipoprotein pattern."
PREDICTIVE VALUE OF LIPOPROTEIN MEASUREMENTS IN CORONARY ATHEROSCLEROSIS. JAMA. 1957;164(10):1098. doi:10.1001/jama.1957.02980100054012