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Article
July 27, 1957

STUDIES ON SIGNIFICANCE OF BIOLOGIC FALSE-POSITIVE REACTION

Author Affiliations

New York

From the Department of Dermatology, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital, and the Vanderbilt Clinic.

JAMA. 1957;164(13):1461-1465. doi:10.1001/jama.1957.02980130037009
Abstract

• The Treponema pallidum immobilization test, a specific means of diagnosing the biologic false-positive reactor, will separate syphilitic from nonsyphilitic patients, within minor limitations. However, the diagnosis of biologic false-positive reactor raises significant questions concerning the patient. Of 555 patients having this diagnosis, 21.6% had systemic disease in one form or another, 2% having systemic lupus erythematosus. Alertness to the finding of a biologic false-positive reaction is indicated, especially in young women; such findings require careful follow-up, including a search for vague signs and symptoms of a previously undiscovered systemic illness.

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