• The Treponema pallidum immobilization test, a specific means of diagnosing the biologic false-positive reactor, will separate syphilitic from nonsyphilitic patients, within minor limitations. However, the diagnosis of biologic false-positive reactor raises significant questions concerning the patient. Of 555 patients having this diagnosis, 21.6% had systemic disease in one form or another, 2% having systemic lupus erythematosus. Alertness to the finding of a biologic false-positive reaction is indicated, especially in young women; such findings require careful follow-up, including a search for vague signs and symptoms of a previously undiscovered systemic illness.
Miller JL, Brodey M, Hill JH. STUDIES ON SIGNIFICANCE OF BIOLOGIC FALSE-POSITIVE REACTION. JAMA. 1957;164(13):1461–1465. doi:10.1001/jama.1957.02980130037009