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Article
July 14, 1956

USE OF HEXAMETHONIUM AND DIBENZYLINE IN DIAGNOSIS AND TREATMENT OF CAUSALGIA

Author Affiliations

Washington, D. C.

From the Neurosurgical Service and Vascular Clinic, Walter Reed Army Hospital. Dr. Fowler is now at the Children's Medical Center, Boston, and Dr. Moser is now in Scarsdale, N. Y.

JAMA. 1956;161(11):1051-1053. doi:10.1001/jama.1956.02970110017006
Abstract

• Twenty-five patients who had a variety of painful conditions in the extremities with some of the characteristics of causalgia were treated with two drugs, hexamethonium and Dibenzyline, commonly classified as sympathetic blocking agents. The hexamethonium was given intravenously; if it relieved the pain, it was followed by Dibenzyline given by mouth.

Six of the patients were completely and permanently relieved of the pain in this way. In 13 there was complete relief during the period of medication but some recurrence of pain thereafter.

Those patients who were not helped by this medication likewise had poor results from later surgical sympathetic blocking or sympathectomy.

These drugs are therefore useful as giving either permanent relief of causalgia or temporary alleviation with valuable prognostic indications.

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