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This book fills the need for a type of book between complete textbooks of the various phases of medicine and the simple outlines of disease entities. It is of a handy size for use as a reference book. The first section, printed on blue paper, lists about 3,200 signs and symptoms in alphabetical order with a reference to pages to be consulted in the text. Each symptom or sign is discussed briefly as to cause and functional derangements. Each disease which can produce the sign or symptom is listed, pathognomic characteristics of the disease are noted, and specific therapeutic advice is included. There are no bibliographic references or illustrations. The sections on chemical poisonings and occupational hazards are particularly commendable. The author has added several new sections to this edition and has revised the text. He has emphasized only the clinical aspect of medical science and has done an excellent
Handbook of Differential Diagnosis. JAMA. 1957;164(15):1722. doi:10.1001/jama.1957.02980150090029