• There were no serious systemic effects after approximately 100 injections of diatrizoate salts for vascular opacification, administered to 83 patients. Local reactions were infrequent and consisted of varying degrees of pain and vasospasm of very brief duration, although the vasospasm never led to ischemic symptoms, and there were no thromboses, even in the distal veins of the extremities. No experimental studies have been performed to determine the possible effect on the spinal cord from large doses of diatrizoate, and it should not be assumed that massive doses of this product will not produce permanent paralysis when injected into the human aorta.
Massell TB, Greenstone SM, Heringman EC. EVALUATION OF DIATRIZOATE (HYPAQUE) IN PERIPHERAL ANGIOGRAPHY AND AORTOGRAPHY. JAMA. 1957;164(16):1749–1752. doi:10.1001/jama.1957.02980160021006