• It is felt that determination of the prostatic acid phosphatase level has not been of value in diagnosing early carcinoma of the prostate. However, as this particular carcinoma becomes more widespread, elevation of the prostatic level does appear. Patients with a persistent elevation of the prostatic acid level above 0.7 units per 100 cc., in whom the diagnosis of carcinoma has been made histologically by biopsy, should be strongly suspected of having metastases, even though clinically the disease appears to be localized. This finding, therefore, would weigh heavily against surgery, other than for the purpose of palliation.
Nobles ER, Kerr WS, Dutoit CH, Rourke GM. SERUM PROSTATIC ACID PHOSPHATASE LEVELS IN PATIENTS WITH CARCINOMA OF THE PROSTATE. JAMA. 1957;164(18):2020-2025. doi:10.1001/jama.1957.02980180022006