By means of a double-blind procedure, 30 obese patients were tested to measure the effectiveness of a new anorexiant. The total weight lost and the average weight lost weekly by each patient were five times as great for those on therapy with the active drug as compared to those on therapy with a placebo. No special stress was placed on diet, although the elements of a well-balanced, 1,100-calorie regimen were explained. There were no unusual side-reactions, subjective complaints, or changes in physical findings to indicate toxicity of the drug.
Ressler C. TREATMENT OF OBESITY WITH PHENMETRAZINE HYDROCHLORIDE, A NEW ANOREXIANT. JAMA. 1957;165(2):135-138. doi:10.1001/jama.1957.02980200015005