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Article
September 21, 1957

REDUCTION IN ELEVATED BLOOD CHOLESTEROL LEVELS BY LARGE DOSES OF NICOTINIC ACIDPRELIMINARY REPORT

Author Affiliations

Madison, Wis.

From the Department of Internal Medicine, Jackson Clinic.

JAMA. 1957;165(3):234-238. doi:10.1001/jama.1957.02980210030009
Abstract

Prompt and sustained reduction of blood cholesterol levels was obtained in nearly all of the hypercholesteremic patients who received large doses of nicotinic acid. Daily doses higher than 3 Gm. of nicotinic acid were required in more than 50% of the patients and in some cases 6 Gm. daily were needed to consistently reduce the blood cholesterol level. No dietary restrictions were imposed in this study. The mechanism by which nicotinic acid produces the observed changes in blood lipids remains obscure.

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