• Acetyldigitoxin was used in 80 patients with heart failure of varying degree and causation. For initial digitalization, 1.5 to 2 mg. was given by mouth in divided doses over a 24-hour period; for maintenance, 0.1 mg. was generally given by mouth once or twice daily. Intravenous administration was tried in a few patients, and the maintenance dose by this route was found to be about two-thirds of the oral maintenance dose.
Anorexia, nausea, and electrocardiographic changes characteristic of digitalis overdosage were observed in 21 sicker patients in whom administration was continued deliberately to the point of therapeutic response or toxic effect. These subjective and objective signs of toxicity generally subsided within 24 to 72 hours. The promptness of their disappearance is an advantageous property of acetyldigitoxin.
Shah SJ, Rubler S, Weston RE. CLINICAL STUDIES ON A NEW CARDIAC GLYCOSIDE, ACETYLDIGITOXIN. JAMA. 1956;161(16):1543-1547. doi:10.1001/jama.1956.02970160023005