Despite the many new antibiotics that have been introduced during recent years, certain sulfonamide preparations still maintain a position of great usefulness in the management of urinary tract infections. Their high degree of effectiveness against the common invaders of the urinary system and their low cost, low toxicity, and ease of administration are a few of the reasons for their wide clinical acceptance.
A recent modification of the basic sulfonamide radical toward greater solubility has led to the development and introduction of Elkosin [N1-(2, 6-dimethyl-4-pyrimidyl) sulfanilamide]. Zeigler, Bagdon, and Shabica1 in an in vitro solubility study of six therapeutically active forms of the commonly used sulfonamides found Elkosin "... clearly the most soluble drug in the entire sulfapyrimidine class in the pH range 4-7." Since infection tends toward a lowering of the urinary pH, this high solubility of Elkosin in the lower physiological ranges is of particular importance
Bogash M, Ellis H, Murphy JJ. ELKOSIN IN THE MANAGEMENT OF URINARY TRACT INFECTIONS. JAMA. 1956;161(16):1564-1565. doi:10.1001/jama.1956.62970160002010a