[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.158.119.60. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
January 11, 1958

EFFECT OF CHLOROTHIAZIDE ON ELECTROLYTE TRANSPORT IN MANITS USE IN THE TREATMENT OF EDEMA OF CONGESTIVE HEART FAILURE, NEPHROSIS, AND CIRRHOSIS

Author Affiliations

From the Department of Medicine of the Presbyterian Hospital, the Francis Delafield Hospital in the City of New York, and the College of Physicians and Surgeons of Columbia University.

JAMA. 1958;166(2):145-152. doi:10.1001/jama.1958.02990020033006
Abstract

Thirty-two hospital patients in advanced states of fluid retention from heart failure, cirrhosis, and nephrosis were given a new sulfonamide compound, chlorothiazide, to induce diuresis. Chlorothiazide, given orally in a dosage of 2.0 Gm. per day, was found to be at least as potent as an organic mercurial agent in promoting diuresis. The compound was effective in all types of edema studied, a finding which perhaps supports the hypothesis that similar mechanisms operate in the abnormal renal retention of sodium in heart failure, hepatic cirrhosis, and nephrosis. Chlorothiazide promises to be useful whenever reduction in stores of body sodium is desirable, and therefore may also be of value in hypertension and in steroid edema. In addition, the compound may contribute to a further understanding of renal tubular mechanisms involved in edema formation, since the study suggests a site of action different from other known diuretics.

×