Of 95 soft tissue tumor lesions at the tip of the nose on which a biopsy was done, 58% were basal cell epitheliomas, and 21 % of these were missed clinically. Difficulty in clinical diagnosis may be due to the fact that the skin over the tip of the nose is thick, adherent to underlying cartilages, and abundantly supplied with sweat and sebaceous glands. Final diagnosis must be made by skin biopsy which reveals the cytology, the architecture, and also the depth to which a neoplasm has invaded the integument.
Haggart HH, Rebello DJA. AIDS IN EARLY DIAGNOSIS OF TUMORS ON TIP OF NOSE. JAMA. 1958;166(9):1010-1013. doi:10.1001/jama.1958.02990090018004