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In the comparatively short period since the clinical introduction of the so-called tranquilizing drugs, the number of workers and the volume of literature in the field of psychopharmacology have expanded at prodigious rates. Much of this work has been devoted to clinical evaluation of new drugs, an effort that has been vastly rewarding despite the general empirical nature of the investigations. The major emphasis of the laboratory studies has been directed toward an elucidation of the basic mechanisms whereby chemical compounds can act on biological systems in such a manner as selectively to influence mental behavior. Many approaches to this highly complex problem have been explored and have resulted in the accumulation of much knowledge concerning the biochemical, pharmacological, physiological, pathological, and psychological effects of the tranquilizing drugs and the hallucinogens. This volume, probably the most ambitious work of its kind to appear to date, presents a comprehensive survey of
Psychopharmacology: Pharmacologic Effects on Behavior. JAMA. 1958;167(17):2151. doi:10.1001/jama.1958.02990340111024