August 23, 1958

Electron Microscopic Atlas of Normal and Leukemic Human Blood

JAMA. 1958;167(17):2152. doi:10.1001/jama.1958.02990340112027

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This is the first comprehensive book dealing with the electron microscopic appearance of normal and leukemic human blood cells. In the introduction, the technique developed by the authors is covered in detail and the general approach of the book, as well as the differences in the interpretation of the appearance of the cells under ordinary light and electron microscopy, is discussed. The appearance of normal blood cells, with magnifications ranging from 8,000 to 280,000, is described in the next section. The normal variations are described and illustrated in detail. The next five sections are devoted to a general description of the appearance of the cells, under various magnifications, in the leukemias before and during treatment. The point is made in this section that the differentiation of the various blast cells is no easier with the electron microscope than with the light microscope. The last two sections describe the plasma cells

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