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To the Editor:—
From 1950 to 1954, studies were made at the Chicago Medical School and at Mount Sinai and Cook County Hospitals (Luisada, Circulation2:872-879 [Dec.] 1950; Luisada and others, ibid. 5:363-369 [March] 1952; Luisada, and Cardi, Circulation Res. 3:510-513 [Sept.] 1955; and Weyl, Illinois M. J.108:265-269 [Nov.] 1955), dealing with antifoaming or defoaming treatment of acute pulmonary edema. A method of treatment was described, based on the use of ethyl alcohol-oxygen vapor inhalation through either an oxygen mask or a nasal tube. The experiments were first conducted in animals with experimental pulmonary edema, then in patients with this clinical condition. The results were excellent, so that later this treatment alone was used in several cases and there was no need to use any other conventional therapy. After publication of these results, antifoaming treatment with silicon aerosol or with aerosols of heavy alcohols were described
Luisada AA. ANTIFOAMING TREATMENT OF PULMONARY EDEMA. JAMA. 1959;169(7):745-746. doi:10.1001/jama.1959.03000240083018