Physicians who prescribe topical nasal medication frequently assume that this type of medicament should always react on nasal mucous membranes in a predictable manner; they are unaware that, while nasal medication is pharmacologically constructed to exert a constant and predictable effect, the nasal environment into which topical nasal medicaments are introduced is far from constant and is continuously subject to change. The degree of response between individual noses given the same dosage of a drug may differ, and the response itself may vary from nose to nose and from time to time.
Intranasal medication has definite indications and purposes. If these are recognized and if the underlying nasal pathological condition is properly evaluated and the medicament employed judiciously used, satisfactory clinical responses are frequently elicited. Nasal vasoconstrictors, for example, are among the more important drugs available for use in the nasal cavity. Nasal vasoconstrictors relieve nasal congestion for varying periods
NASAL MEDICATION. JAMA. 1959;169(9):956. doi:10.1001/jama.1959.03000260054013