[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.158.119.60. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
February 13, 1960

IMMUNIZATION IN VIRAL HEPATITIS

Author Affiliations

Philadelphia

From the Department of Pediatrics, School of Medicine, University of Pennsylvania, and the Children's Hospital of Philadelphia.

JAMA. 1960;172(7):652-655. doi:10.1001/jama.1960.03020070010003
Abstract

It is paradoxical that zinc-precipitated gamma globulin administered in small doses apparently could protect the recipient against epidemic hepatitis while the same material may produce serum hepatitis. Cold-ethanolfractionated gamma globulin does not produce serum hepatitis but protects almost all exposed susceptible persons against the more severe symptoms of epidemic hepatitis. The most likely explanation is that in the carrier state hepatitis viruses of more than one antigenic strain are present in the blood stream and that the recipient of the carrier's blood can be protected by gamma globulin in accordance with how closely the transfused virus strain is antigenically related to the strain or strains responsible for epidemic hepatitis. The so-called passive-active immunization afforded by gamma globulin in epidemic hepatitis seems promising, and a method of testing it in closed institutions is proposed.

×