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The authors of this volume describe indications, techniques, precautions, errors, and complications in connection with biopsies in general and for specific regions. They emphasize the importance of taking a sufficiently large piece of tissue or multiple pieces without crushing or tearing and furnishing of pertinent clinical information to the pathologist so that he can make studies necessary for proper diagnosis. They recognize the need in some cases for studies on fresh unfixed tissues to find bacteria, fungi, or even viruses. They also call attention to the importance, especially in office practice, of prompt fixation in a suitable fixative of the ordinary routine biopsy specimen, taken, as a rule, to determine the presence or absence of malignancy. Various fixatives and their formulas and uses are described. The addition of 10 Gm. of sodium bicarbonate to one gallon of 10% formalin, as suggested by the authors, is not to be recommended however.
Biopsy Manual. JAMA. 1960;172(7):765–766. doi:10.1001/jama.1960.03020070123039