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February 20, 1960

Chemistry of Pancreatic Diseases

JAMA. 1960;172(8):883. doi:10.1001/jama.1960.03020080113035

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This book attempts to integrate the clinical, physiological, and biochemical knowledge of pancreatic diseases. This is a vast undertaking, and the author has met with varying degrees of success in his efforts. The exposition on exocrine pancreatic function is complete and excellently presented. The references to the recent applications of electron microscopy and ultracentrifugation techniques indicate the comprehensiveness of this section, but the discussion of endocrine pancreatic function is largely concerned with the details of insulin and carbohydrate metabolism and is somewhat cursory. The clinical section, particularly the part on the management of diabetes mellitus, is overly brief, and such interesting entities as the Zollinger-Ellison syndrome and hemochromatosis are not mentioned. In the concluding discussion, on neoplastic diseases of the pancreas, clinical deficiencies are evident from the omissions of the important diagnostic techniques of duodenal intubation and cytological and biochemical studies of the pancreatic fluid before and after stimulation. The

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