March 12, 1960

Metabolic Aspects of Renal Function

JAMA. 1960;172(11):1220. doi:10.1001/jama.1960.03020110104030

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This well-written and comprehensive monograph deals with transport of phosphate, amino acid, organic acids and bases in the cells of the renal tubules, and the tricarboxylic acid cycle in the kidney. The chapter dealing with the effects of phlorhizin is excellent. The author assumes a familiarity with basic ideas in cellular metabolism and renal tubular secretion and reabsorption. The kidney is a remarkable organ which excretes almost completely many phenolic substances such as iodine compounds used in urography and found in paraaminohippurate. Since excretion of these involves work, and excretion parallels blood flow, the renal metabolism varies with blood flow. The progress being made in the study of this organ's curious metabolic behavior is concisely described and fullydocumented in this book.

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