[Skip to Content]
[Skip to Content Landing]
July 14, 1962

Oral Prolonged-Action Medication

Author Affiliations

Ottawa, Canada

JAMA. 1962;181(2):102-105. doi:10.1001/jama.1962.03050280032005b

THERE ARE OBVIOUS ADVANTAGES to the physician if he is able to prescribe certain drugs in preparations which in one dose contain a sufficient amount of medication to last all day or all night. Although enteric-coated tablets probably represent the first attempt to alter the release of drugs, a variety of drugs are available now in prolonged, sustained, delayed, repeat-action, and timed-release dosage forms. Enthusiastic advertisements for some of these products, which may be generally considered as having prolonged-action, purport to describe just when and how much of a drug is released, and simplified curves of blood levels or clinical response claim to depict how the preparation will act in vivo. Since these products usually contain the equivalent of 3 normal doses of the drug, it is of considerable importance to the physician to know that the drug will actually be released in the advertised manner and not released either

First Page Preview View Large
First page PDF preview
First page PDF preview