July 14, 1962

Oral Prolonged-Action Medication

Author Affiliations

Ottawa, Canada

JAMA. 1962;181(2):102-105. doi:10.1001/jama.1962.03050280032005b

THERE ARE OBVIOUS ADVANTAGES to the physician if he is able to prescribe certain drugs in preparations which in one dose contain a sufficient amount of medication to last all day or all night. Although enteric-coated tablets probably represent the first attempt to alter the release of drugs, a variety of drugs are available now in prolonged, sustained, delayed, repeat-action, and timed-release dosage forms. Enthusiastic advertisements for some of these products, which may be generally considered as having prolonged-action, purport to describe just when and how much of a drug is released, and simplified curves of blood levels or clinical response claim to depict how the preparation will act in vivo. Since these products usually contain the equivalent of 3 normal doses of the drug, it is of considerable importance to the physician to know that the drug will actually be released in the advertised manner and not released either

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