Data from 27 patients were analyzed in order to determine the relation of adrenal cortical hypofunction to the occurrence of allergic disorders. This group was selected on the basis of evidence of allergic disease, obtained either from the case record or from a personal interview, out of a total of 496 who had been found to have adrenal cortical hypofunction. Among the 496 there were 18 in whom the existing allergic disease showed no correlation with adrenal cortical function and 27 in whom there was (1) a definite time-relation between full development of the hypofunction and appearance or intensification of the allergic disorder or (2) improvement in the allergic disorder as treatment for adrenal cortical hypofunction was implemented. The latter most commonly were in the form of atopic reactions. In 8 of the 27 patients with adrenal cortical hypofunction the administration of cortisone or adrenal extracts ameliorated the atopic symptoms.
Carryer HM, Sherrick DW, Gastineau CF. OCCURRENCE OF ALLERGIC DISEASE IN PATIENTS WITH ADRENAL CORTICAL HYPOFUNCTION. JAMA. 1960;172(13):1356-1360. doi:10.1001/jama.1960.03020130014005