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June 11, 1960


JAMA. 1960;173(6):684-685. doi:10.1001/jama.1960.03020240072016

Soft tissue calcification is a subject of broad and fundamental interest. It has been treated generally from the point of view of supposed etiology, mainly as to whether this represents a general systemic disease in which calcium deposition occurs because of increased serum calcium content (metastatic) or whether it represents a change in local tissue reactions (dystrophic or degenerative). Localized calcification from changes in tissue response is related to infection; local vascular change, as in chronic venous insufficiency; trauma; and tissue degeneration of aging. In some diffuse systemic diseases there may be extensive soft tissue calcifications which are purely dystrophic in type, notably subcutis calcification or ossification, or both, in dermatomyositis and scleroderma and arterial wall calcification in atherosclerosis.

It is universally believed that degenerative tissue disease of aging occurs earlier and is more extensive in patients with diabetes. The occurrence of arterial calcification in a patient with diabetes would

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