Fifty-seven patients underwent surgical removal of a pulmonary histoplasmoma because the possibility of malignancy could not be excluded without thoracotomy. The surgeon must orient himself before the operation, for the patient with histoplasmosis is usually asymptomatic, while the thoracotomy sometimes leaves residual discomfort that outweighs previous complaints. The histories of five patients, all men between the ages of 18 and 40 years, illustrate the course of the disease and the results of surgery. There were no characteristic findings at operation which specifically identified the histoplasmoma; the diagnosis was made by identifying Histoplasma capsulatum in the excised nodules. The average hospital stay for the 57 patients was 158 days. Of those whose progress was followed up for two to seven years after operation, only three reported major respiratory complaints.
Forsee JH, Pfotenhauer M. SURGICAL MANAGEMENT OF FOCALIZED PULMONARY HISTOPLASMOSIS. JAMA. 1960;173(8):878–883. doi:10.1001/jama.1960.03020260018005