It is proposed that Wegener's granulomatosis be considered a clinicopathological triad, since it involves primarily three systems: vascular, respiratory, and renal. Pathologically, it is a focal necrotizing vasculitis which involves both arteries and veins and produces necrotizing granulomas of the respiratory tract and a focal glomerulonephritis. Clinically, it is manifested by intractable rhinitis and sinusitis, nodular pulmonary lesions, and terminal uremia. The recognition of these findings as a triad facilitates earlier diagnosis. The criteria outlined were fulfilled in the case, here presented, of a 57-year-old man. The treatment included administration of antibiotics and steroids, but did not appear to affect the outcome of the disease. The etiology is unknown.
McDonald JB, Edwards RW. "WEGENER'S GRANULOMATOSIS"—A TRIAD. JAMA. 1960;173(11):1205-1209. doi:10.1001/jama.1960.03020290031006