This study concerned 56 patients with localized swelling in an upper or lower extremity occurring after thrombophlebitis, ulcer of the leg, radical mastectomy, trauma, or fracture. There was no reason for believing that cardiorenal disease or hypoproteinemia contributed to the edema in these cases. Appropriate local treatment was supplemented with diuretics, generally chlorothiazide, and restriction of oral salt intake. All patients showed measurable decrease in their edema, and the response was good or excellent in all but six. Particular advantage was found in the ambulatory management of ulcers of the leg. The improvement of these edematous extremities by systemic therapy points to the likelihood of significant systemic factors in the symptomatology of these cases.
Bedell WC. TREATMENT OF EDEMATOUS EXTREMITY WITH DIURETICS. JAMA. 1960;173(16):1811–1813. doi:10.1001/jama.1960.03020340029008