Sixty cases of staphylococcic infection occurring during a 12-month period were treated with vaccine therapy and evaluated as follows: 5 cases of failure, 11 cases of improvement, and 44 cases of excellent response. The antigenicity of the vaccine depended on the use of a mild killing agent, avoiding subculture of the vaccine strain, standardizing the vaccine density before killing the organisms, and shaking the vaccine cell suspension during the incubation period. Autogenous vaccine prepared in the manner described offers a valuable therapeutic agent for recurring, persistent severe infections due to staphylococcic organisms.
McCoy KL, Kennedy ER. Autogenous Vaccine Therapy in Staphylococcic Infections. JAMA. 1960;174(1):35-38. doi:10.1001/jama.1960.03030010037010