One hundred and four diabetic patients of both sexes, ranging in age from 4 to 83 years, were studied for seven months in a private office practice to evaluate the effect of phenformin therapy. Most of these patients had had difficulty in controlling their diabetes before taking phenformin. Fair to excellent control was achieved by 91 (88%) with or without adjunctive exogenous insulin; failures which occurred in 13 cases were attributable to gastrointestinal, behavioral, or environmental difficulties. Special importance was attached to the value of combined phenformininsulin therapy in reducing the incidence and severity of hypoglycemic episodes and in improving the control of previously labile patients.
Barclay PL. Clinical Evaluation of Phenformin (DBI) in Office Practice. JAMA. 1960;174(5):474–480. doi:10.1001/jama.1960.03030050016005