This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
In the June 11 issue of the British Medical Journal, page 1807, appeared a report by Drs. John Watt and Elliot E. Philipp of five cases of intrauterine fetal death which occurred in patients with toxemia of pregnancy who were taking chlorothiazide. These authors implied in their communication that these fetal deaths were related to the use of the oral diuretics.
In his comments regarding the above communication, published in the July 9 issue of the same journal on page 148, Dr. R. T. Sears stated that, while diuretics remove some of the manifestations of the disease, they do not attack directly its cause. He further stated that the intrauterine deaths may have been caused by the placental changes which occur in toxemia and may have had no relation to the use of diuretics. Because of the many inquiries which have been made regarding these controversial communications, it seems desirable
Assali NS. THIAZIDE DIURETICS IN TOXEMIA OF PREGNANCY. JAMA. 1960;174(7):887–888. doi:10.1001/jama.1960.03030070065018