November 5, 1960


Author Affiliations

National Institutes of Health Bethesda, Md.

JAMA. 1960;174(10):1348. doi:10.1001/jama.1960.03030100116036

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To the Editor:—  It has become evident (Bloch and Bunim: J. A. M. A.169:307 [Jan. 24] 1959; Lane and Decker: J. A. M. A.173:982 [July 2] 1960) that the term "bentonite flocculation test" (BFT) is being used exclusively to denote the test for rheumatoid arthritis reported by Bozicevich, Bunim, Freund, and Ward in 1958 (Proc. Soc. Exper. Biol. & Med.97:180 [Jan.] 1958). This designation is erroneous in that the bentonite in this test serves merely as a carrier system for the F II fraction of serum and this same carrier system has been used with other substances in performing flocculation tests. Bentonite flocculation was first used in testing for antibodies to trichina in 1951 (Bozicevich and others: Pub. Health Rep.66:806 [June 22] 1951) and, more recently, with desoxyribonucleic acid (DNA) in testing for antinuclear factors in the serum of patients with systemic

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