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November 12, 1960

Diagnosis and Treatment of Urinary Tract Infection in ChildrenA Group of 74 Children with Recurrent Infections Were Studied To Aid in Planning a Therapeutic Program

Author Affiliations


From the Department of Urology, The Cleveland Clinic Foundation and The Frank E. Bunts Educational Institute.

JAMA. 1960;174(11):1377-1381. doi:10.1001/jama.1960.03030110005002

Inadequately treated, persistent, or recurrent urinary tract infections in childhood probably account for many cases of unexplained chronic pyelonephritis producing renal insufficiency in adult life. A group of 74 children with recurrent or persistent urinary tract infections were studied to aid in planning a therapeutic program. Of 18 children treated with long-term antimicrobial therapy and double-voiding techniques when reflux was present, 17 had sterile urine at the time of follow-up. These results were better than those in the group treated by antimicrobial therapy plus urethral dilatation or plastic surgery on the vesical neck with or without reimplantation of the ureter. A program for investigation and therapy utilizing this information is presented for the management of urinary tract infection in children.