Inadequately treated, persistent, or recurrent urinary tract infections in childhood probably account for many cases of unexplained chronic pyelonephritis producing renal insufficiency in adult life. A group of 74 children with recurrent or persistent urinary tract infections were studied to aid in planning a therapeutic program. Of 18 children treated with long-term antimicrobial therapy and double-voiding techniques when reflux was present, 17 had sterile urine at the time of follow-up. These results were better than those in the group treated by antimicrobial therapy plus urethral dilatation or plastic surgery on the vesical neck with or without reimplantation of the ureter. A program for investigation and therapy utilizing this information is presented for the management of urinary tract infection in children.
Straffon RA, Engel WJ. Diagnosis and Treatment of Urinary Tract Infection in ChildrenA Group of 74 Children with Recurrent Infections Were Studied To Aid in Planning a Therapeutic Program. JAMA. 1960;174(11):1377–1381. doi:10.1001/jama.1960.03030110005002