A single intravenous solution containing 5% glucose, 0.66% sodium chloride, and 2% protein has been used for the parenteral fluid therapy of 28 patients with second- and third-degree burns involving 15% or more of the body surface area. Only the rate of administration must be changed to accommodate the size of the patient and the extent of the burn. Only one death occurred during the first 48 hours. Because this solution replaces water, salt, and protein continuously at the same rates at which they are being lost from the circulation, it has theoretical advantages over other regimens which replace these factors discontinuously by alternate infusions of plasma, saline, or dextrose and water. Its greatest value lies in the ease of management and the virtual absence of fluid and electrolyte problems.
Eagle JF, Schenck WG, Shim W. Parenteral Fluid Therapy of BurnsUse of a Single Solution During First Forty-eight Hours. JAMA. 1960;174(12):1589–1592. doi:10.1001/jama.1960.03030120029006