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December 3, 1960

Thrombocytopenic Purpura Due to Cat-Scratch DiseaseCase Reports of Three Brothers Who Were Continuously Exposed To Eleven Farm Cats

Author Affiliations

New York City

From the Lawrence Hospital, Bronxville, N. Y.; Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York City; and the Babies Hospital, New York City.

JAMA. 1960;174(14):1824-1826. doi:10.1001/jama.1960.03030140046009

Thrombocytopenic purpura occurred in one of three siblings affected by catscratch disease. All were treated with sulfisoxazole; in addition, one received tetracycline and the other two received chloramphenicol. One who had received sulfisoxazole and chloramphenicol developed thrombocytopenic purpura. Spontaneous return of the platelet level to normal preceded subsidence of the basic infection in this case. The authors give reasons for believing that platelet depression was a complication of the underlying infection rather than coincidental or secondary to the antibiotic therapy.