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January 7, 1961


JAMA. 1961;175(1):42-44. doi:10.1001/jama.1961.03040010044013

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Samuel J. Kimura, of the Department of Ophthalmology, University of California School of Medicine, presents a review of the literature on the uveal tract, covering the period from August, 1958, to September, 1959 (Arch Ophthal63:571 [Mar.] 1960).

The behavior of mast cells in the uveal tract was investigated in experimental studies by Larsen. The normal uvea in his experiments showed mast cells in varying amounts in the same species of animals. The highest number was found in the choroid; the ciliary body showed less, and the iris still less. In guinea pigs treated with large doses of cortisone, the mast cells showed degranulation and vacuolization of the cytoplasm and clumping of granules. Similar changes were observed in guinea pigs made vitamin-C deficient. This knowledge of the behavior of the mast cell may lead to better understanding of inflammatory and allergic diseases of the uveal tract.

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