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January 7, 1961

Attenuated Infection: The Germ Theory in Contemporary Perspective

JAMA. 1961;175(1):68. doi:10.1001/jama.1961.03040010070028

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This work is a compilation and analysis of data concerning the host-parasite relationship. The author considers attenuated infection to be a "state of truce or peaceful coexistence between the host and the infecting agent." This phenomenon is manifested in the carrier state, microbial persistence, and latent infections. Many experimental and clinical observations pertinent to the problem have been reviewed and are discussed at length. A single volume summing up this complicated literature should be welcome in the field of infectious diseases.

In some ways this book fulfills its purpose. Dr. Simon clearly defines his terms in the introduction and uses them in a consistent manner throughout the text. The approach is logical and orderly, indicating care and forethought. Examples given to support a point are lucid. The list of references and the bibliographic index are of value. The major shortcoming is a lack of restraint on the part of the

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