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January 28, 1961

Laboratory Procedures and Therapy in Coronary Thrombosis

Author Affiliations

Miami Beach, Fla.

From the Department of Medicine, University of Miami School of Medicine, Jackson Memorial Hospital, Miami, Florida and the Coagulation Research Laboratory, Miami Heart Institute.

JAMA. 1961;175(4):279-283. doi:10.1001/jama.1961.03040040011002

Recently interest has been expressed in the possibility of reducing the damage to the myocardium after an infarction by the use of fibrinolytic therapy. At this time activator appears to be the ideal thrombolytic agent. Data obtained from 3 patients with acute myocardial infarction are presented. All were treated with fibrinolytic therapy. A rise in the level of fibrinolytic activity was manifested by changes in several components of the clotting system and by increased areas of lysis on heated fibrin plates. Other evidence of improvement included a rapid fall in serum transaminase values.