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February 4, 1961

Intranasal Oxytocin in Obstetrics

Author Affiliations


From the Department of Obstetrics and Gynecology, Western Reserve University School of Medicine. Dr. Pose is from the University of Montevideo, Uruguay, on a traveling grant from the Rockefeller Foundation.

JAMA. 1961;175(5):384-387. doi:10.1001/jama.1961.03040050040009

Brief exposures to synthetic oxytocin, applied intranasally as a spray, were used in 74 cases of induced labor, 138 cases for enhancement of labor, 39 cases for testing sensitivity to oxytocin, and 15 cases for enhancement of prelabor. The purpose was to obtain a mild stimulation of uterine activity, usually for 15 to 20 minutes. The method of application is remarkably simple, and the authors recommend it as having a wide degree of safety in determining the degree of labor readiness of a patient at term, in inducing labor (in combination with amniotomy), and especially in combating mild degrees of secondary inertia which appear during labor.