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To the Editor:—
One of the questions answered in The Journal, July 23, 1960, p. 1395, concerns adrenochrome, and your consultant states in his answer that no double-blind study has been made of the use of this material as a preventive of bleeding. I should like to call your attention to page 29 of Medical Digest for February, 1959, in which a paper by J. Calnan and associates (Brit J Plast Surg11:87-96, 1958) is abstracted. The abstract describes a double-blind study of adrenochrome monosemicarbazone, and concludes, "There was no effect on bleeding at operation exerted by the drug."
Deutsch ME. Adrenochrome. JAMA. 1961;175(5):415. doi:10.1001/jama.1961.03040050071028