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To the Editor:—
A 19-year-old Canadian worker who had been exposed to paints and solvents for at least a year showed marked pallor and hemosiderotic tinge. The liver was felt 2 fingerbreadths below the costal margin; the spleen was not palpable. Blood tests showed the following findings: hemoglobin level, 5 Gm.%; red blood cell count, 1,770,000 per cubic millimeter; white blood cell count, 1,250, with 2% band forms, 21% neutrophils, and 77% lymphocytes; and platelets, 45,000 per cubic millimeter ( measured by the direct method ). Repeated bonemarrow aspirations and one surgical biopsy specimen showed severely hypoplastic bone marrow. The serum iron level was 227 mcg.%. The serum contained agglutinins against homologous white cells and platelets at a titer of 1/32 and 1/128 respectively. There were no incomplete or coating antibodies against homologous red cells. The patient had received at least 200 transfusions over the past three years.One hundred mg. of
Stefanini M, Mueller L, Lemieux J. Hypoplastic Anemia. JAMA. 1961;175(6):529. doi:10.1001/jama.1961.03040060103036