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February 25, 1961

Enzymes in Health and Disease

JAMA. 1961;175(8):732. doi:10.1001/jama.1961.03040080088035

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The subject here comprises the basis of the universe of living things, their function, malfunction, interrelations, and susceptibility to manipulation; the whole of biological basic science and clinical medicine approached from the micromolecularphysicochemical viewpoint.

Each contributor is a specialist who was asked to bring thoughts from his field of knowledge which would be of most interest to students of enzymes in health and disease.

The contributions are well prepared, explained, and illustrated and cover fundamental and clinical aspects of "molecular disease," glutamic acid and glucose metabolism in brain, cancer growth, serum enzymes, relief of thrombosis and tissue inflammation, débridement of wounds and burns, blood clotting, fibrinolytic systems, penicillinase, treatment of respiratory diseases including asthma, and many other things. It sounds confusing, but enzymes are everywhere and if an enzyme can't do what you want done, it probably isn't worth fooling with.

Collagenase, if available, would be the best agent to

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