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To the Editor:—
Thank you for affording me the opportunity to reply to Doctor Albrecht whose views deserve serious consideration. I have received correspondence from other public health officers who share Doctor Albrecht's concern about our recommendations for increasing the dose of gamma globulin in the prevention of infectious hepatitis.Our suggestion for increasing the dose of gamma globulin from 0.01 ml. to 0.06 ml. per pound of body weight was based on our personal evaluation of (1) the results of our studies (JAMA174:823, 1960) and (2) the results of controlled studies reported in the literature. Unfortunately, controlled observations on the efficacy of intermediate doses between 0.01 ml. and 0.06 ml. are not available. It is possible that a dose of 0.02 ml. or 0.04 ml. of gamma globulin per pound of body weight may prove to be as effective as the 0.06-ml. dose. The data to support
Krugman S. Gamma Globulin in Hepatitis. JAMA. 1961;175(9):824-825. doi:10.1001/jama.1961.03040090084030