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The skin holds many clues for the diagnosis of internal disease. Hemangiomata of the face may indicate vascular disease of the brain. Pigmentation of the oral mucosa suggests polyposis of the gastrointestinal tract. Neurofibromata of the skin may lead to the diagnosis of spinal cord or renal artery compression by a deeper neurofibroma. Skin color changes may signify dysfunction of the liver or various endocrine glands. There are many skin clues of internal disease if physicians look for and recognize them. In this issue of The Journal, p. 864, attention is directed to the multi-system vascular disease, angiokeratoma corporis diffusum, in which a typical skin lesion is external evidence of internal disease. Formerly this skin abnormality was regarded only as a dermatological entity, but as this disease has been more carefully studied, its multi-system nature has been disclosed.
As old diseases are further studied and new syndromes investigated, and as our detailed knowledge
ANOTHER MULTI-SYSTEM DISEASE. JAMA. 1961;175(10):902. doi:10.1001/jama.1961.03040100066017