In patients maintained on long-term anticoagulant therapy the prevention and management of bleeding after dental surgery frequently poses a vexing problem. Results of experience with the intravenous and oral administration of estrogens in 9 such patients are here set forth, and 3 case histories are given in some detail. In most cases the preparation for dental surgery included stopping the oral administration of the anticoagulant for several days and increasing the dose of orally administered estrogen, if the patient had been taking it. Conjugated equine estrogens were administered half an hour before the extraction and given again several hours after.
Roberts HJ. Control of Bleeding After Dental Extraction During Anticoagulant TherapyWith Particular Reference to Estrogenic Prophylaxis. JAMA. 1961;175(11):962–966. doi:10.1001/jama.1961.03040110026006