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March 18, 1961

Effect of Conjugated Estrogens on the Coagulation Mechanism

Author Affiliations


From the Anesthesia Laboratories of the Harvard Medical School at the Massachusetts General Hospital, and the Children's Medical Service, Massachusetts General Hospital.

JAMA. 1961;175(11):1011-1012. doi:10.1001/jama.1961.63040110012021b

IT HAS BEEN reported that the intravenous injection of conjugated estrogens (Premarin) is useful in the control of surgical bleeding in man.1 It has also been reported that in dogs2 the intravenous injection of conjugated estrogens is followed within 2 hours by significant elevation of factor V (labile factor) and prothrombin. There are no published data on the effect of intravenously administered conjugated estrogens on the coagulation system in human beings, although some authors have suggested that there may be a beneficial effect.1, 3 In the present report the effect of intravenously given conjugated estrogens on these and other factors in normal man is investigated.

Methods  Blood was obtained by venipuncture using the 2-syringe technique. Prothrombin times were determined by the Quick one-stage method.4 The percentage activity was determined from a dilution curve of normal plasma using aluminum hydroxide-absorbed normal plasma as the diluent. Factor V

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