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March 18, 1961

The Dyslipidoses

JAMA. 1961;175(11):1029. doi:10.1001/jama.1961.03040110093047

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The increasing interest in disturbances of lipid metabolism (designated by Fleischmajer as "the dyslipidoses") makes this book particularly timely. Although it would appear unusual for such a work to emanate from a department of dermatology, the author rightly points out that historically the earliest descriptions of altered fat metabolism were contributed by those observing skin manifestations of these diseases.

Beginning with a remarkably clear succinct survey of the biochemistry and metabolism of lipids, the author proceeds to a description of the cutaneous and tendon xanthomas and thereupon to an interesting classification of the dyslipidoses based on biochemical and clinical grounds. This is followed by chapter length discussions of the various diseases and syndromes listed in the classification. A rewarding aspect is the attempt to integrate our known histochemical, physiologic, biochemical, and genetic knowledge with clinical observations and treatment of the diseases described.

Dermatologic manifestations are perhaps overemphasized in a work

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