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April 1, 1961

New Drugs and Developments in Therapeutics

A Council on Drugs' Digest
Author Affiliations

Scientific data were supplied to the Council by Astra Pharmaceutical Products, Inc. (dextriferron); Cutter Laboratories (plasma protein fraction, human); Endo Laboratories Inc. (oxymorphone hydrochloride); E. Fougera and Company, Inc. (bunamiodyl sodium); and Mead Johnson & Co. (methdilazine hydrochloride).

JAMA. 1961;175(13):1170-1171. doi:10.1001/jama.1961.63040130008012a
Abstract

Intravenous Iron  Since the withdrawal of iron-dextran complex and the consequent unavailability of a satisfactory preparation of iron for intramuscular injection, intravenously administered hematinics have assumed increased importance. Dextriferron (Astrafer), an iron-carbohydrate complex, is one of the newer of these. It induces a hematological response comparable to that produced by other parenterally given iron compounds: The hemoglobin concentration increases, after a latent period of 3 to 7 days, at a rate inversely proportional to the initial value; maximum reticulocyte response occurs during the first week of therapy and remains high for some time.Although, as pointed out in the Council's statement on iron-dextran complex (JAMA175:388 [Feb. 4] 1961), intravenous administration of iron is accompanied by a higher incidence and greater severity of side-effects than is intramuscular injection, dextriferron seems to be somewhat better tolerated than saccharated iron oxide. Immediate reactions, usually resulting from too rapid administration, include flushing

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